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protected from moisture
ARP-4692 is derived from the
lentiviral packaging vector pHP-1dl.28 (refer to attached figure from Gene
Ther.) with an additional 695 base pair env
deletion (NdeI-AseI). This lentiviral helper construct generates HIV-1 Gag-Pol,
Tat, Rev, Vpr, Vif, and Vpu. It is derived from pUC18-based pNL4-3 with
deletions of 5', U3, 5'UTR, part of env,
nef and the 3' LTR. This construct is
11,729 base pairs including the insert and is ampicillin resistant. Bacteria
transformed with this construct are prone to deletions when grown at 37°C with
vigorous shaking. Cultures should be grown at 32°C with gentle overnight
shaking. This construct can be propagated in DH5α, Top-10, HB101 or STBL2. For additional
details please refer to the protocol for DNA transfection for production of
recombinant lentiviruses and the provided plasmid map and sequence files.
Each vial of ARP-4692 contains
approximately 5 µg of dried purified DNA stabilized in DNAstable®PLUS. Please refer to the appropriate
data sheet for lot-specific information.
Chang, L.-J., et al. “Efficacy and Safety Analyses of a
Recombinant Human Immunodeficiency Virus Type 1 Derived Vector System.” Gene Ther. 6 (1999): 715-728.
Scientists at for-profit institutions or who intend
commercial use of this reagent must contact UF Innovate at the following email
before the reagent can be released.
When applying for permits and forms please:
Do NOT reference NIH HIV Reagent Program or ATCC Catalog Numbers in the Material Description
fields found on the permits and/or forms.
Make sure your name and address on the permit applications and/or forms are exactly
as they appear on your NIH HIV Reagent Program registration.
Information about permits is provided as a courtesy to NIH HIV Reagent Program customers.
While we use reasonable efforts to include accurate and up-to-date information on
this page, we make no warranties or representation as to its accuracy.
For more information on the necessary compliance requirements associated with the
biological materials provided by NIH HIV Reagent Program, please select this link: Compliance Requirements.
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